Provisional riders and teams have been announced for the MotoGP™ class in 2016.
| RACE NO. | RIDER | NATIONALITY | TEAM | MACHINE |
| 4 | ANDREA DOVIZIOSO | ITALIAN | DUCATI RACING TEAM | DUCATI |
| 6 | STEFAN BRADL | GERMAN | APRILIA RACING TEAM GRESINI | APRILIA |
| 8 | HECTOR BARBERA | SPANISH | AVINTIA RACING | DUCATI |
| 9 | DANILO PETRUCCI | ITALIAN | OCTO PRAMAC RACING | DUCATI |
| 15 | ALEX DE ANGELIS | SAN MARINO | IODARACING PROJECT | ART |
| 19 | ALVARO BAUTISTA | SPANISH | APRILIA RACING TEAM GRESINI | APRILIA |
| 25 | MAVERICK VINALES | SPANISH | TEAM SUZUKI ECSTAR | SUZUKI |
| 26 | DANI PEDROSA | SPANISH | REPSOL HONDA TEAM | HONDA |
| 29 | ANDREA IANNONE | ITALIAN | DUCATI RACING TEAM | DUCATI |
| 35 | CAL CRUTCHLOW | BRITISH | LCR HONDA | HONDA |
| 38 | BRADLEY SMITH | BRITISH | MONSTER YAMAHA TECH 3 | YAMAHA |
| 41 | ALEIX ESPARGARO | SPANISH | TEAM SUZUKI ECSTAR | SUZUKI |
| 43 | JACK MILLER | AUSTRALIAN | MARC VDS RACING TEAM | HONDA |
| 44 | POL ESPARGARO | SPANISH | MONSTER YAMAHA TECH 3 | YAMAHA |
| 45 | SCOTT REDDING | BRITISH | OCTO PRAMAC RACING | DUCATI |
| 46 | VALENTINO ROSSI | ITALIAN | MOVISTAR YAMAHA MotoGP | YAMAHA |
| 50 | EUGENE LAVERTY | IRISH | ASPAR MotoGP TEAM | DUCATI |
| 53 | TITO RABAT | SPANISH | ESTRELLA GALICIA 0,0 MARC VDS | HONDA |
| 68 | YONNY HERNANDEZ | COLOMBIAN | ASPAR MotoGP TEAM | DUCATI |
| 76 | LORIS BAZ | FRENCH | AVINTIA RACING | DUCATI |
| 93 | MARC MARQUEZ | SPANISH | REPSOL HONDA TEAM | HONDA |
| 99 | JORGE LORENZO | SPANISH | MOVISTAR YAMAHA MotoGP | YAMAHA |